An Angiogenic Role for the Neurokines Midkine and Pleiotrophin in Tumorigenesis
نویسنده
چکیده
Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survivaL To examine a role for MK and the related pleiotrophin(PTN) in tumorigenesis,they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular density and endothelial proliferati@n, implicating an angiogenic role for MK and FIN. Angiogenic activity of MK and PTN was confirmed in the rabbit corned assay. Our data therefore identify two novel targets for antiangiogenic drug devel opment.
منابع مشابه
An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis.
Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular d...
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